abstract：:Adaptation to low oxygen conditions is essential for maintaining homeostasis and viability in oxygen-consuming multi-cellular tissues, including solid tumors. Central in these processes are the hypoxia-inducible transcription factors, HIF-1 and HIF-2, controlling genes involved in e.g. glucose metabolism and neovascul...

journal_title：Experimental cell research

authors： Löfstedt T,Fredlund E,Noguera R,Navarro S,Holmquist-Mengelbier L,Beckman S,Påhlman S,Axelson H

更新日期：2009-07-01 00:00:00

abstract：:Ubiquitylation of membrane receptors is recognised as a critical post-translational modification, governing their regulation and function. Following ubiquitylation, membrane proteins may be internalised, recycled or degraded via lysosomal or proteasomal pathways. Viruses have appropriated these cellular pathways as a ...

journal_title：Experimental cell research

authors： Nathan JA,Lehner PJ

更新日期：2009-05-15 00:00:00

abstract：:It has been known for at least 20 years that growth factors induce the internalization of cognate receptor tyrosine kinases (RTKs). The internalized receptors are then sorted to lysosomes or recycled to the cell surface. More recently, data have been published to indicate other intracellular destinations for the inter...

journal_title：Experimental cell research

authors： Carpenter G,Liao HJ

更新日期：2009-05-15 00:00:00

abstract：:Recruitment of mesenchymal stem cells (MSC) to tissue damages is a promising approach for in situ tissue regeneration. The physiological mechanisms and regulatory processes of MSC trafficking to injured tissue remain poorly understood. However, the pivotal role of chemokines in MSC recruitment has already been shown. ...

journal_title：Experimental cell research

authors： Binger T,Stich S,Andreas K,Kaps C,Sezer O,Notter M,Sittinger M,Ringe J

更新日期：2009-05-01 00:00:00

abstract：:A novel protein that associates with interphase nucleus and mitotic apparatus (INMAP) was identified by screening HeLa cDNA expression library with an autoimmune serum followed by tandem mass spectrometry. Its complete cDNA sequence of 1.818 kb encodes 343 amino acids with predicted molecular mass of 38.2 kDa and nume...

journal_title：Experimental cell research

authors： Shen E,Lei Y,Liu Q,Zheng Y,Song C,Marc J,Wang Y,Sun L,Liang Q

更新日期：2009-04-15 00:00:00

abstract：:The Alternative Reading Frame (ARF) protein suppresses tumorigenesis through p53-dependent and p53-independent pathways. Most of ARF's anti-proliferative activity is conferred by sequences in its first exon. Previous work showed specific amino acid changes occurred in that region during primate evolution, so we progra...

journal_title：Experimental cell research

authors： di Tommaso A,Hagen J,Tompkins V,Muniz V,Dudakovic A,Kitzis A,Ladeveze V,Quelle DE

更新日期：2009-04-15 00:00:00

abstract：:Bax, a multi-domain pro-apoptotic Bcl-2 family member, is a key regulator for the release of apoptogenic factors from mitochondria. MOAP-1, which was first isolated from a screen for Bax-associating proteins, interacts with Bax upon apoptotic induction. MOAP-1 is a short-lived protein that is constitutively degraded b...

journal_title：Experimental cell research

authors： Lee SS,Fu NY,Sukumaran SK,Wan KF,Wan Q,Yu VC

更新日期：2009-04-15 00:00:00

abstract：:Regions of heterochromatin are often found at the periphery of the mammalian nucleus, juxtaposed to the nuclear lamina. Genes in these regions are likely maintained in a transcriptionally silent state, although other locations at the nuclear periphery associated with nuclear pores are sites of active transcription. As...

journal_title：Experimental cell research

authors： Lee DC,Welton KL,Smith ED,Kennedy BK

更新日期：2009-04-01 00:00:00

abstract：:Microparticles are small membrane-bound vesicles that are released from apoptotic cells during blebbing. These particles contain DNA and RNA and display important functional activities, including immune system activation. Furthermore, nucleic acids inside the particle can be analyzed as biomarkers in a variety of dise...

journal_title：Experimental cell research

authors： Reich CF 3rd,Pisetsky DS

更新日期：2009-03-10 00:00:00

abstract：:Melanoma development is a multi-step process arising from a series of genetic and epigenetic events. Although the sequential stages involved in progression from melanocytes to malignant melanoma are clearly defined, our current understanding of the mechanisms leading to melanoma onset is still incomplete. Growing evid...

journal_title：Experimental cell research

authors： Serafino A,Balestrieri E,Pierimarchi P,Matteucci C,Moroni G,Oricchio E,Rasi G,Mastino A,Spadafora C,Garaci E,Vallebona PS

更新日期：2009-03-10 00:00:00

abstract：:Hypoxia can activate the endothelium toward a pro-inflammatory phenotype and enhance leukocyte adhesion. This process is involved in pathological conditions such as vascular remodeling or ischemia-reperfusion injury. This study was aimed to obtain a global picture of the response of the endothelial cells to hypoxia wi...

journal_title：Experimental cell research

authors： Flamant L,Toffoli S,Raes M,Michiels C

更新日期：2009-03-10 00:00:00

abstract：:An implantation-competent blastocyst, several hours prior to its attachment on the uterine wall, transmits signals to surrounding uterine cells and vice-versa to initiate a two-way interaction. The language of this precocious dialogue is versatile, taking advantage of secreted molecules for long-range interactions and...

journal_title：Experimental cell research

authors： Lim HJ,Dey SK

更新日期：2009-02-15 00:00:00

abstract：:Products of the Neuregulin-1 (Nrg-1) gene, along with the ErbB family of receptor tyrosine kinases through which Nrg-1 ligands signal, play a critical role during cardiovascular development. Through studies of genetically manipulated mice, as well as studies in cells isolated from adult hearts, it appears that Nrg-1/E...

journal_title：Experimental cell research

authors： Pentassuglia L,Sawyer DB

更新日期：2009-02-15 00:00:00

abstract：:This review article describes the pathways and mechanisms of endocytosis and post-endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family. Growth factor binding to EGFR accelerates its internalization through clathrin-coated pits which is followed by the efficient lysosomal targeting of...

journal_title：Experimental cell research

authors： Sorkin A,Goh LK

更新日期：2009-02-15 00:00:00

abstract：:Satellite cells are a quiescent heterogeneous population of mononuclear stem and progenitor cells which, once activated, differentiate into myotubes and facilitate skeletal muscle repair or growth. The Transforming Growth Factor-beta (TGF-beta) superfamily members are elevated post-injury and their importance in the r...

journal_title：Experimental cell research

authors： Schabort EJ,van der Merwe M,Loos B,Moore FP,Niesler CU

更新日期：2009-02-01 00:00:00

abstract：:The tumor suppressor function of p53 is disabled in the majority of tumors, either by a point mutation of the p53 gene, or via MDM2-dependent proteasomal degradation. We have screened a chemical library using a cell-based assay and identified a low molecular weight compound named MITA which induced wild-type p53-depen...

journal_title：Experimental cell research

authors： Hedström E,Issaeva N,Enge M,Selivanova G

更新日期：2009-02-01 00:00:00

abstract：:KRIT1 is a disease gene responsible for Cerebral Cavernous Malformations (CCM). It encodes for a protein containing distinct protein-protein interaction domains, including three NPXY/F motifs and a FERM domain. Previously, we isolated KRIT1B, an isoform characterized by the alternative splicing of the 15th coding exon...

journal_title：Experimental cell research

authors： Francalanci F,Avolio M,De Luca E,Longo D,Menchise V,Guazzi P,Sgrò F,Marino M,Goitre L,Balzac F,Trabalzini L,Retta SF

更新日期：2009-01-15 00:00:00

abstract：:The bone marrow represents an easy accessible source of adult stem cells suitable for various cell based therapies. Several studies in recent years suggested the existence of pluripotent stem cells within bone marrow stem cells (BMSC) expressing marker proteins of both embryonic and tissue committed stem cells. These ...

journal_title：Experimental cell research

authors： Sauerzweig S,Munsch T,Lessmann V,Reymann KG,Braun H

更新日期：2009-01-01 00:00:00

abstract：:LMX1B is a LIM-homeodomain transcription factor essential for development. Putative LMX1B target genes have been identified through mouse gene targeting studies, but their identity as direct LMX1B targets remains hypothetical. We describe here the first molecular characterization of LMX1B target gene regulation. Micro...

journal_title：Experimental cell research

authors： Rascle A,Neumann T,Raschta AS,Neumann A,Heining E,Kastner J,Witzgall R

更新日期：2009-01-01 00:00:00

abstract：:Four and one half LIM domain protein FHL2 participates in many cellular processes involved in tissue repair such as regulation of gene expression, cytoarchitecture, cell adhesion, migration and signal transduction. The repair process after wounding is initiated by the release of peptides and bioactive lipids. These mo...

journal_title：Experimental cell research

authors： Kirfel J,Pantelis D,Kabba M,Kahl P,Röper A,Kalff JC,Buettner R

更新日期：2008-12-10 00:00:00

abstract：:The inhibition of apoptosis by Toxoplasma gondii is governed by its modulation of several signaling cascades including the NFkappaappaB and JNK pathways. This is evident in the dysregulation of JNK activation following treatment with UV and TNFalpha, both apoptogenic stimuli. Infection-mediated interference with the J...

journal_title：Experimental cell research

authors： Carmen JC,Southard RC,Sinai AP

更新日期：2008-12-10 00:00:00

abstract：:Collagen VI is a survival factor for skeletal muscle produced by endomysial cells and localized in connective tissue around muscle fibers. Mutations of its genes (COL6A1, COL6A2 and COL6A3) cause two muscular disorders, Bethlem myopathy and Ullrich disease. Expression of Collagen VI is highly dynamic during developmen...

journal_title：Experimental cell research

authors： Braghetta P,Ferrari A,Fabbro C,Bizzotto D,Volpin D,Bonaldo P,Bressan GM

更新日期：2008-11-15 00:00:00

abstract：:Transforming growth factor beta regulates many biological processes including cell motility and invasion. Podosomes are specialized F-actin rich structures found in normal cells, such as osteoclasts and macrophages. Tumor cells often form related structures called invadopodia that are thought to promote invasion and m...

journal_title：Experimental cell research

authors： Mandal S,Johnson KR,Wheelock MJ

更新日期：2008-11-15 00:00:00

abstract：:Src-family kinases, cytoplasmic enzymes that participate in various signaling events, are found at not only the plasma membrane but also subcellular compartments, such as the nucleus, the Golgi apparatus and late endosomes/lysosomes. Lyn, a member of the Src-family kinases, is known to play a role in DNA damage respon...

journal_title：Experimental cell research

authors： Ikeda K,Nakayama Y,Togashi Y,Obata Y,Kuga T,Kasahara K,Fukumoto Y,Yamaguchi N

更新日期：2008-11-01 00:00:00

abstract：:Spindle assembly is essential for the equal distribution of genetic material to the daughter cells during mitosis. The process of spindle assembly is complicated and involves multiple levels of molecular regulation. It is generally accepted that mitotic spindles are emanated from the centrosomes and are assembled in t...

journal_title：Experimental cell research

authors： Yang CP,Fan SS

更新日期：2008-10-15 00:00:00

abstract：:Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase that plays a key role in cellular processes such as cell adhesion, migration, proliferation and survival. Recent studies have also implicated FAK in the regulation of cell-cell adhesion. Here, evidence is presented showing that siRNA-mediated suppression of...

journal_title：Experimental cell research

authors： Playford MP,Vadali K,Cai X,Burridge K,Schaller MD

更新日期：2008-10-15 00:00:00

abstract：:Epidermal growth factor (EGF) has been shown to be a potent mitogen for epidermal cells both in vitro and in vivo, thus contributing to the development of an organism. It has recently become clear that peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) expression and activation is involved in the c...

journal_title：Experimental cell research

authors： Liang P,Jiang B,Yang X,Xiao X,Huang X,Long J,Zhang P,Zhang M,Xiao M,Xie T,Huang X

更新日期：2008-10-15 00:00:00

abstract：:The migration and proliferation of vascular smooth muscle cells (vSMCs) are critical events in neointima formation during atherosclerosis and restenosis. The transcription factor nuclear factor of activated T-cells-isoform c1 (NFATc1) is regulated by atherogenic cytokines, and has been implicated in the migratory and ...

journal_title：Experimental cell research

authors： Chow W,Hou G,Bendeck MP

更新日期：2008-10-01 00:00:00

abstract：:The ST6Gal-I glycosyltransferase, which adds alpha2-6-linked sialic acids to glycoproteins, is overexpressed in colon adenocarcinoma, and enzyme activity is correlated with tumor cell invasiveness. Previously we reported that forced expression of oncogenic ras in HD3 colonocytes causes upregulation of ST6Gal-I, leadin...

journal_title：Experimental cell research

authors： Shaikh FM,Seales EC,Clem WC,Hennessy KM,Zhuo Y,Bellis SL

更新日期：2008-10-01 00:00:00

abstract：:UNC5H receptors (UNC5H1, UNC5H2, UNC5H3) are putative tumor suppressors whose expression is lost in numerous cancers. These receptors have been shown to belong to the so-called family of dependence receptors. Such receptors induce apoptosis when their ligand netrin-1 is absent, thus conferring a state of cellular depe...

journal_title：Experimental cell research

authors： Maisse C,Rossin A,Cahuzac N,Paradisi A,Klein C,Haillot ML,Hérincs Z,Mehlen P,Hueber AO

更新日期：2008-08-15 00:00:00

abstract：:The mechanisms that structure the mammalian endoplasmic reticulum (ER) network are not fully understood. Here we show that salt extraction of semi-intact normal rat kidney (NRK) fibroblasts and subsequent incubation of the extracted cells with ATP resulted in dramatic ER network retraction. Under these conditions, add...

journal_title：Experimental cell research

authors： Baughman C,Morin-Leisk J,Lee T

更新日期：2008-08-15 00:00:00

abstract：:Claudins belong to a large family of transmembrane proteins that localize at tight junctions (TJs) where they play a central role in regulating paracellular transport of solutes and nutrients across epithelial monolayers. Their ability to regulate the paracellular pathway is highly influenced by changes in extracellul...

journal_title：Experimental cell research

authors： Lim TS,Vedula SR,Hui S,Kausalya PJ,Hunziker W,Lim CT

更新日期：2008-08-15 00:00:00

abstract：:We previously identified a novel centrosomal protein CPAP, which carries a 112-residue motif that is essential for microtubule destabilization. In this report, we define both the microtubule (MT) binding and destabilizing domains in human CPAP and analyze the mutations that affect its MT-destabilizing activity. Analys...

journal_title：Experimental cell research

authors： Hsu WB,Hung LY,Tang CJ,Su CL,Chang Y,Tang TK

更新日期：2008-08-15 00:00:00

abstract：:L1 cell adhesion molecule (L1-CAM) is a transmembrane cell adhesion molecule initially defined as a promigratory molecule in the developing nervous system. L1 is also overexpressed in a variety of human carcinomas and is associated with bad prognosis. In carcinoma cell lines L1 augments cell motility and metastasis, t...

journal_title：Experimental cell research

authors： Gast D,Riedle S,Kiefel H,Müerköster SS,Schäfer H,Schäfer MK,Altevogt P

更新日期：2008-08-01 00:00:00

abstract：:Insulin-like growth factor binding proteins (IGFBPs) have various IGF-independent cellular activities, including receptor-independent cellular uptake followed by transcriptional regulation, although mechanisms of cellular entry remain unclear. Herein, we focused on their receptor-independent cellular entry mechanism i...

journal_title：Experimental cell research

authors： Goda N,Tenno T,Inomata K,Shirakawa M,Tanaka T,Hiroaki H

更新日期：2008-08-01 00:00:00

abstract：:3-phosphoinositide-dependent kinase-1 (PDK1) phosphorylates and activates several kinases in the cAMP-dependent, cGMP-dependent and protein kinase C (AGC) family. Many putative PDK1 substrates have been identified, but have not been analyzed following transient and specific inhibition of PDK1 activity. Here, we demons...

journal_title：Experimental cell research

authors： Tamgüney T,Zhang C,Fiedler D,Shokat K,Stokoe D

更新日期：2008-07-01 00:00:00

abstract：:O-GlcNAc transferase (OGT)-mediated modification of protein Ser/Thr residues with O-GlcNAc influences protein activity, similar to the effects of phosphorylation. The anti-apoptotic Akt1 is both activated by phosphorylation and modified with O-GlcNAc. However, the nature and significance of the Akt1 O-GlcNAc modificat...

journal_title：Experimental cell research

authors： Kang ES,Han D,Park J,Kwak TK,Oh MA,Lee SA,Choi S,Park ZY,Kim Y,Lee JW

更新日期：2008-07-01 00:00:00

abstract：:Mammalian stanniocalcin-2 (STC2) is a secreted glycoprotein hormone with a putative role in unfolded protein response and apoptosis. Here we reported that STC2 expression was sporadically abrogated in human cancer cells by transcriptional silencing associated with CpG island promoter hypermethylation. Direct sequencin...

journal_title：Experimental cell research

authors： Law AY,Lai KP,Ip CK,Wong AS,Wagner GF,Wong CK

更新日期：2008-05-01 00:00:00

abstract：:Mutation R453W in A-type lamins, that are major nuclear envelope proteins, generates Emery-Dreifuss muscular dystrophy. We previously showed that mouse myoblasts expressing R453W-lamin A incompletely exit the cell cycle and differentiate into myocytes with a low level of multinucleation. Here we attempted to improve d...

journal_title：Experimental cell research

authors： Favreau C,Delbarre E,Courvalin JC,Buendia B

更新日期：2008-04-01 00:00:00

abstract：:The protein tyrosine kinase Ack1 has been linked to cancer when over-expressed. Ack1 has also been suggested to function in clathrin-mediated endocytosis and in down-regulation of the epidermal growth factor (EGF) receptor (EGFR). We have studied the intracellular localization of over-expressed Ack1 and found that Ack...

journal_title：Experimental cell research

authors： Grøvdal LM,Johannessen LE,Rødland MS,Madshus IH,Stang E

更新日期：2008-04-01 00:00:00